OxyContin® (Extended-Release Oxycodone): Uses, Dosage Ranges, and Safety

OxyContin® is an extended-release formulation of oxycodone prescribed for the management of severe, chronic pain that requires continuous, around-the-clock opioid therapy when alternative treatments are inadequate. Because of its potency and risk of dependence, it must be used strictly under the supervision of a licensed healthcare professional.

For opioid-naïve adults, treatment commonly begins at 10 mg every 12 hours. OxyContin is available in several strengths, including 10 mg, 15 mg, 20 mg, 30 mg, 40 mg, 60 mg, and 80 mg, all taken twice daily at 12-hour intervals. Dose increases are made cautiously, based on pain control, prior opioid exposure, and tolerability. Higher doses, particularly 60 mg and 80 mg, are generally reserved for opioid-tolerant patients only.

Older adults, and patients with kidney or liver impairment or interacting medications, often require lower starting doses and slower titration. Tablets must be swallowed whole—they should never be crushed, chewed, or split, as this can cause rapid drug release and overdose. Common side effects include constipation, nausea, dizziness, and drowsiness; serious risks include respiratory depression and dependence.